Central carbohydrate metabolism in Sulfolobus spp.


Central carbohydrate metabolism in Sulfolobus spp.


Julian Quehenberger, Lu Shen, Sonja-Verena Albers, Bettina Siebers and Oliver Spadiut


Julia Koblitz


Carbohydrate Metabolism and TCA Cycle Carbohydrate Metabolism and TCA Cycle

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Uploaded on 23rd of January 2020


Central carbohydrate metabolism in Sulfolobus spp. The pathways for hexose and pentose degradation as well as glycogen, trehalose, and pentose formation are shown. D-arabinose (dashed lines) can only be utilized as carbon source by S. solfataricus and not by S. acidocaldarius. The current understanding of regulation by effectors is indicated by green stars and red boxes for activator and inhibitors, respectively. Enzymes catalyzing different reactions are depicted as numbers: (1) glucose dehydrogenase (broad substrate specificity); (2) gluconate dehydratase; (3) 2-keto-3-deoxygluconate kinase; (4) 2-keto-3-deoxy-(6-phospho) gluconate aldolase (broad substrate specificity); (5) non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase; (6) glyceraldehyde-3-phosphate dehydrogenase; (7) phosphoglycerate kinase; (8) phosphoglycerate mutase; (9) glyceraldehyde:ferredoxin oxidoreductase; (10) glycerate kinase; (11) enolase; (12) pyruvate kinase; (13) phosphoenolpyruvate synthetase; (14) pyruvate:ferredoxin oxidoreductase; (15) triosephosphate isomerase; (16) fructose-1,-6-bisphosphate aldolase/phosphatase; (17) phosphoglucose/phosphomannose isomerase; (18) phosphoglucomutase/phosphomannomutase; (19) NTP-glucose-1-phosphate uridylyltransferase; (20) glycogen synthase; (21) glycogen phosphorylase; (22) glucan-1,4-a-glucosidase; (23) hexokinase; (24) maltooligosyltrehalose synthase/maltooligosyltrehalose trehalohydrolase; (25) D-arabinose dehydrogenase; (26) D-arabinoate dehydratase; (27) L-arabinoate/D-xylonate dehydratase; (28) glycolaldehyde dehydrogenase/glycolaldehyde:ferredoxin oxidoreductase; (29) glycolate dehydrogenase; (30) 2-keto-3-deoxy-arabinoate/xylonate dehydratase; (31) a-ketoglutarate semi-aldehyde dehydrogenase; (32) citrate synthase; (33) aconitase; (34) isocitrate dehydrogenase; (35) a-ketoglutarate:ferredoxin oxidoreductase; (36) succinyl-CoA synthetase; (37) succinate dehydrogenase; (38) fumarase; (39) malate dehydrogenase; (40) isocitrate lyase; (41) malate synthetase. EMP, Embden–Meyerhof–Parnas; ED, Entner–Doudoroff; spED, semi-phosphorylative ED; npED, non-phosphorylative ED; RuMP, reversed ribulose monophosphate; TCA, tricarboxylic acid; G1P, glucose 1-phosphate; G6P, glucose 6-phosphate; F6P, fructose 6-phosphate; DHAP, dihydroxyacetone phosphate; GAP, glyceraldehyde 3-phosphate; BPG, 1,3-bisphosphoglycerate; 3-PG, 3-phosphoglycerate; 2-PG, 2-phosphoglycerate; PEP, phosphoenolpyruvate; D-KDG, 2-keto-3-deoxy-D-gluconate; D-KDGal, 2-keto-3-deoxy-D-galactonate; D-KDPG, 2-keto-3-deoxy-6-phosphate-D-gluconate; D-KDPGal, 2-keto-3-deoxy-6-phosphate-D-galactonate; L-KDA, 2-keto-3-deoxy-L-arabinoate; D-KDA, 2-keto-3-deoxy-D-arabinoate; D-KDX, 2-keto-3-deoxy-D-xylonate; a-KGSA, a-ketoglutarate semi-aldehyde.

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